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Toronto: A Canadian research team claims to be developing an oral drug for diabetes that absorbs insulin similar to an injected dose.
The breakthrough was announced in a press release issued by the University of British Columbia (UBC), which stated, “Researchers have found that insulin in the latest version of an oral tablet is absorbed by rats in the same way as injected insulin. “.
The research team was led by Inca Principal Investigator Dr. Anubhav Pratap-Singh, UBC’s School of Land and Food Systems.
The first part of the study was also published in the journal Scientific Reports.
Dr Pratap-Singh, who studied chemical engineering at IIT-Kharagpur, said: “These exciting results show that we are developing an insulin formulation that no longer needs to be injected before every meal, thereby improving the quality of life. , and more than 900 people worldwide. mental health of people with type 1 diabetes.”
He said the inspiration for the study came from his father, a diabetic who has required insulin injections three to four times a day for the past 15 years.
Development of the pill has not yet entered human trials, so a timeline for the final product has yet to be determined. However, Dr Pratap-Singh said oral tablets would be “more sustainable, cost-effective and accessible” if successfully delivered.
While testing other oral insulin alternatives globally, the UBC team focused on “how to promote higher absorption rates.”
Instead of swallowing, this particular tablet is placed between the gum and the cheek, allowing it to dissolve. “This method utilizes the membranes that line the inner cheeks and the back of the lips (also known as the buccal mucosa). It delivers all of the insulin to the liver without wasting or breaking down any insulin,” the UBC press release said.
Dr. Alberto Baldelli, a senior researcher in Dr. Pratap-Singh’s lab, said they are now seeing almost 100 percent of the insulin in the pills go directly to the liver, whereas in previous attempts to develop drinkable insulin, the majority ended up in the stomach. “Similar to rapid-acting insulin injections, our orally administered tablets are absorbed after half an hour and can last about two to four hours,” Dr. Baldelli said.
Dr Pratap-Singh hopes their process can “reduce the cost per dose of insulin” because their “oral alternative may be cheaper and easier to manufacture”.
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